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Single-dose amoxycillin in the treatment of bacteriuria in pregnancy and the puerperium--a controlled clinical trial

Masterton RG, Evans DC, Strike PW

British journal of obstetrics and gynaecology, 1985

Abstract

Ninety obstetric patients with significant bacteriuria were treated randomly with either a single dose of 3 g amoxycillin or with a conventional course of ampicillin over 7 days. Treatment groups were comparable in terms of age, gravidity and socioeconomic status, and the outcome of pregnancy in the two groups did not differ significantly. Cure rates, assessed at 1 week and 6 weeks after treatment, were not significantly different: 88% for single-dose treatment and 84% for conventional treatment. It is concluded that a single dose of 3 g amoxycillin is a safe, effective and acceptable treatment for bacteriuria in pregnancy and the puerperium.

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Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.

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