Treatment of advanced gastrointestinal cancer with genetically modified autologous mesenchymal stem cells - TREAT-ME-1 - a phase I, first in human, first in class trial
Abstract
// Jobst C. von Einem 1 , Sylvia Peter 2 , Christine Günther 2 , Hans-Dieter Volk 3 , Gerald Grütz 3 , Christoph Salat 4 , Oliver Stoetzer 4 , Peter J. Nelson 5 , Marlies Michl 1 , Dominik P. Modest 1 , Julian W. Holch 1 , Martin Angele 6 , Christiane Bruns 7 , Hanno Niess 6,* and Volker Heinemann 1,* 1 Department of Medical Oncology and Comprehensive Cancer Center, University Hospital Grosshadern, LMU, Munich, Germany 2 Apceth GmbH & Co. KG, Munich, Germany 3 Institute for Medical Immunology and Berlin-Brandenburg Center for Regenerative Medicine, Charité-Universitätsmedizin, Berlin, Germany 4 Haemato-Onkologische Schwerpunktpraxis Prof. Salat, Dr. Stoetzer, Munich, Germany 5 Department of Medicine IV, University Hospital of Munich, LMU, Munich, Germany 6 Department of Surgery, University Hospital Grosshadern, LMU, Munich, Germany 7 General, Visceral and Cancer Surgery, University Hospital of Cologne, Cologne, Germany * These authors have contributed equally to this article Correspondence to: Jobst C. von Einem, email: // Keywords : mesenchymal stem cells, gastrointestinal cancer, CCC, CRC, GDEPT Received : May 10, 2017 Accepted : August 26, 2017 Published : September 16, 2017 Abstract Purpose: This phase I, first in human, first in class clinical study aimed at evaluating the safety, tolerability and efficacy of treatment with genetically modified mesenchymal stromal cells (MSC) in combination with ganciclovir (GCV). MSC_apceth_101 are genetically modified autologous MSCs…
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