Role of SGLT2 inhibitors (gliflozins) in heart failure
Abstract
Gliflozins (sodium-glucose cotransporter type 2 inhibitors or SGLT2is) reduced hospitalisations for heart failure in all large prospective cardiovascular outcome trials performed in patients with type 2 diabetes at risk of cardiovascular disease. This protective effect was confirmed in two dedicated trials that specifically targeted patients with heart failure and reduced left ventricular ejection fraction (DAPA-HF with dapagliflozin and EMPEROR-reduced with empagliflozin) and in two trials in patients with preserved left ventricular ejection fraction (EMPEROR-preserved with empagliflozin and DELIVER with dapagliflozin), independently of the presence of diabetes. These favourable results contribute to give a privileged position to SGLT2is in recent international guidelines produced by diabetologists and cardiologists.
Les gliflozines (inhibiteurs des cotransporteurs sodium-glucose de type 2 (iSGLT2)) réduisent les hospitalisations pour insuffisance cardiaque (IC) dans tous les grands essais prospectifs chez les patients avec diabète de type 2 à risque cardiovasculaire. Les effets ont été confirmés dans 2 essais ciblant spécifiquement les patients avec IC à fraction d’éjection réduite (DAPA-HF avec la dapagliflozine et EMPEROR-Reduced avec l’empagliflozine) et dans 2 essais chez des patients à fraction d’éjection préservée (EMPEROR-Preserved avec l’empagliflozine et DELIVER avec la dapagliflozine), qu’ils soient diabétiques ou non. Ces résultats favorables ont donné aux…
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Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
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