#1054 Impact of SLGT2 inhibitors in kidney transplant patients: a single center experience
Abstract
Recent landmark studies such as CREDENCE, EMPA-REG, and DAPA-CKD have demonstrated that sodium-glucose cotransporter-2 inhibitors (SGLT2i) are relatively safe, with minimal side effects, and provide substantial benefits in diabetic patients with chronic kidney disease (CKD). These benefits include reduced proteinuria, slower decline in kidney function, and decreased cardiovascular events and mortality.
However, data on the effects of SGLT2i in diabetic kidney transplant recipients remain scarce. This study aims to evaluate the safety and efficacy of SGLT2i by comparing two groups of diabetic kidney transplant patients: those receiving SGLT2i versus those not receiving SGLT2i.
This was an observational retrospective single-center study including an initial cohort of 473 diabetic kidney transplant recipients. Of these, we identified 45 patients who had been taking SGLT2i for at least six months. These patients were matched with a control group of 45 diabetic kidney transplant recipients who were not taking SGLT2i. Matching criteria included age, gender, baseline serum creatinine at the time of SGLT2i initiation, and time since transplantation.
Exclusion criteria were patients with type 1 diabetes or other diabetes mellitus modalities (LADA or MODY) (n = 41); patients with multiple organ transplant (n = 7); patients taking SGLT2i for less of six months (n = 19) and patients who lost of follow-up (n = 6).
Primary outcomes were assessed at 6 months and 12 months and included:…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 90 participants or records.
Read the paper
Related studies
- Risk Factors for Coronavirus Disease 2019 (COVID-19) Death in a Population Cohort Study from the Western Cape Province, South Africa
- Global and regional estimates of genital human papillomavirus prevalence among men: a systematic review and meta-analysis
- A methodology for assessing deployment trauma and its consequences in OEF/OIF/OND veterans: The TRACTS longitudinal prospective cohort study
- Post‑COVID‑19 Syndrome in Outpatients: a Cohort Study
- Factors Influencing Primary and Secondary Implant Stability—A Retrospective Cohort Study with 582 Implants in 272 Patients
- Electroacupuncture for Painful Diabetic Peripheral Neuropathy: A Multicenter, Randomized, Assessor-Blinded, Controlled Trial
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.