Pharmacologic pain management strategies for reducing postoperative pain in total knee arthroplasty: a systematic review from molecular mechanisms to clinical efficiency
Abstract
Introduction: The aim of this systematic review was to evaluate the efficiency of different analgetic regimes used in clinical practice in reducing postoperative pain and cumulative opioid consumption following total knee arthroplasty (TKA).
Materials and methods: A systematic search was conducted on PubMed, Embase and Scopus according to PRISMA guidelines in order to identify appropriate studies published between 2010 and 2025, which investigated different oral or intravenous analgesic strategies (duloxetine, acetaminophen, corticosteroids, opioids, nonsteroidal anti-inflammatory drugs (NSAIDs) and gabapentinoids) in populations of patients receiving TKA by having as primary outcome the quantification of postoperative pain scores or opioid consumption.
Results: Out of the 1069 identified articles, 63 met the inclusion criteria. Duloxetine improved pain scores following TKA and reduced opioid consumption, however without reaching clinical relevance. Acetaminophen, despite moderate evidence for its efficiency, remains one of the most commonly used analgesics following TKA. Gabapentinoids are useful in reducing chronic neuropathic pain, but lack efficiency in the acute clinical setting. Opioids, although highly prescribed, fail to demonstrate a clinical benefit. Intravenous corticosteroids can also provide significant pain relief due to extensive anti-inflammatory properties, while NSAIDs remain one of the mainstays of treatment due to the relevant opioid-sparing effect and…
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Evidence Hub reads this as a systematic review, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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