A systematic review and meta-analysis of the effect of acupuncture therapy on the symptoms and immune indicators of ankylosing spondylitis
Abstract
Background and objective: Ankylosing spondylitis (AS) is a chronic inflammatory disorder affecting sacroiliac joints, vertebral structures, paraspinal soft tissues, and peripheral joints. This study systematically investigated the mechanism of action of inflammatory factors underlying combined acupuncture therapy for AS, evaluating its impact on clinical manifestations and immune parameters.
Methods: A comprehensive literature search was conducted across PubMed, Embase, Cochrane Library, SinoMed, CNKI, Wanfang, and VIP databases using keywords related to acupuncture and AS. Randomized controlled trials (RCTs) were screened using EndNote X9. The Cochrane RoB 2 tool, GRADE assessed methodological quality. Meta-analysis was performed in Stata 15.0, employing mean difference (MD), standardized mean difference (SMD), or relative risk (RR) with fixed- or random-effects models based on I2 heterogeneity. Publication bias was evaluated via funnel plots and Egger's test, and subgroup analyses were conducted where applicable.
Results: Fifty-two RCTs were included, of which 20 exhibited low risk of bias. Meta-analysis demonstrated that acupuncture, alone or combined with medication, significantly reduced pain (VAS: MD = -1.26, 95% CI [-1.44, -1.09]), inflammatory markers (CRP: MD = -3.49, [-4.12, -2.85]; ESR: MD = -5.36, [-6.82, -3.89]), and morning stiffness duration (MD = -1.32, [-1.87, -0.78]). Improvements were also observed in BASDAI, BASFI, IL-1, IL-6, IL-17, TNF-α, and IgA…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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