Lactiplantibacillus Plantarum PD01 Supplementation Reduces Microplastics and Microplastic-associated Chemicals in Humans: A Randomized, Double-blind, Placebo-controlled Trial
Abstract
The study attempts to conduct randomized double-blind controlled trials to understand whether daily exposure to microplastics (MPs) can cause potential impacts on human health, explore whether the intake of Lactiplantibacillus plantarum PD01 can alleviate potential obesity-related damages caused by MPs, and provide a scientific basis for the prevention and nutritional intervention of health hazards caused by MP exposure.
Conditions: Intestinal Functional Disorder, Inflammation.
Primary outcome: Fecal microplastics (MPs) levels as assessed by Py-GC/MS; Measurement of Urinary PAE Metabolites Using UHPLC-MS/MS; Gut microbiota composition as assessed by Fecal Metagenomics; Blood metabolic profiles as assessed by Blood Metabolomics; Inflammatory cytokines and immune markers; Blood biochemical indicators as assessed by the Mindray BS200 automatic biochemical analyzer; Routine blood examination (Five-part differential); Body composition measured by using InBody770.
Enrollment: 96 participants.
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 96 participants or records.
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