Arsenic exposure and bladder cancer: quantitative assessment of studies in human populations to detect risks at low doses
Abstract
While exposures to high levels of arsenic in drinking water are associated with excess cancer risk (e.g., skin, bladder, and lung), exposures at lower levels (e.g., 10 µg/L for more than one-third of a lifetime. By contrast, for all study subjects, relative risks predicted for one-half of lifetime exposure to 50 µg/L were just above the upper 95% CI on the SRRE. Thus, results from low-exposure studies, particularly for never smokers, were statistically inconsistent with predicted risk based on high-dose extrapolation. Additional studies that better characterize tobacco use and stratify analyses of arsenic and bladder cancer by smoking status are necessary to further examine risks of arsenic exposure for smokers.
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- Green Chemistry: A Framework for a Sustainable Future
- Nano/micro-plastic, an invisible threat getting into the brain
- Emerging contaminants antibiotic resistance genes and microplastics in the environment: Introduction to 21 review articles published in CREST during 2018–2022
- Water Resources and Sustainable Development
- Nano- and microplastics in the workplace
- Water Enclosure and World-Literature: New Perspectives on Hydro-Power and World-Ecology
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.