Risk factors for gastric cancer: an umbrella review of systematic reviews and meta-analyses
Abstract
Background: This umbrella review aims to critically appraise and synthesize epidemiological evidence from meta-analyses to identify and classify risk and protective factors associated with gastric cancer.
Methods: PubMed, Embase, Web of Science, and the Cochrane were used to search, including meta-analyses up to April 2024. Emphasis was placed on non-interventional studies, and the inclusion criteria focused on meta-analyses that involved diverse ethnic groups and genders from various countries and settings. Two reviewers independently evaluated the methodological quality using the AMSTAR tool and classified evidence strength based on established criteria.
Results: Of 245 meta-analyses meeting inclusion criteria, 117 unique risk factors were identified, including 77 significantly associated factors (42 adverse and 35 protective) and 40 non-significant factors. 17 (14.5%) risk factors were classified as class I or II evidence in this umbrella review. Protective factors included cruciferous vegetable intake, total cholesterol (TC), HDL cholesterol (HDL-C), NSAIDs, β-carotene, vitamins, and dietary polyphenols. Risk factors included depression, Helicobacter pylori (Hp) infection, dermatomyositis, and Graves' disease. Class III evidence confirmed that aspirin, non-aspirin NSAIDs, soy food intake, non-fermented soy food intake, physical activity, vitamin A, ginseng, dietary fiber, tooth brushing frequency, folate, and green tea consumption were associated with reduced GC risk.…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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