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Seeing elephants and drinking water from a porcelain vase - A case of septin-7 antibody-associated encephalitis presenting as a severe disorganized psychosis

A. Gaebler, Friederike A. Arlt, M. Scharf, S. Wolking, Yvonne Weber, Simone C. Tauber, Marieluise Kirchner, Philipp Mertins et al.

Translational Psychiatry, 2026

Abstract

Identifying autoimmune encephalitis (AIE) in patients with predominant psychiatric symptoms poses a diagnostic challenge for psychiatrists and neurologists, especially when CSF and MRI fi ndings are inconclusive. We report a case of septin-7 AIE presenting as steroid-responsive psychosis, whose de fi nite diagnosis could only be made years after onset

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