Fluoroquinolone Antimicrobial Agent Levofloxacin in Veterinary Medicine and its Pharmacokinetic-Pharmacodynamic Studies. Doctoral Thesis
Abstract
In medicine, antibacterial agents represent one of the most important classes of drugs. Fluoroquinolones are among the most widely used antimicrobials. Levofloxacin is a third-generation fluoroquinolone for the use in human medicine, but it has certain applications in veterinary medicine worldwide. This Thesis is a compilation of four scientific publications aimed at investigating the suitability of levofloxacin as an antimicrobial agent in the veterinary field, and to evaluate its properties and activity in animal species, where it has not been previously comprehensively studied. Narratively, the first publication was a scientific literature review assessing the role of levofloxacin in veterinary medicine, covering the status of levofloxacin use in veterinary medicine worldwide, its antimicrobial activity, resistance problems, pharmacokinetics, tissue residues, adverse effects and drug interactions. The second publication was an experimental evaluation of the levofloxacin pharmacokinetic profiles in 6 clinically healthy rabbits after the 5 mg/kg intravenous, intramuscular and subcutaneous administration using the crossover study design. Additionally, the effects of single levofloxacin administration on tear production and osmolarity were measured. In this study levofloxacin showed high clearance (0.60 mL/g/h) and complete bioavailability after extravascular administration. The third publication assessed the pharmacokinetic profiles of levofloxacin in healthy geese (2 groups…
How strong is the evidence?
Evidence Hub reads this as a thesis, done in animal and cell cultures (in vitro), not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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