COVID-19 Vaccine in Immunosuppressed Adults With Autoimmune Diseases
Abstract
This study will evaluate the Moderna RNA-based COVID-19 vaccine currently approved by Health Canada in people with rheumatic diseases. This study will help understand what the side effects of the vaccine in these patients are, and what is their capacity to develop antibodies that may confer protection from the COVID-19 disease.
Conditions: Covid19, Rheumatic Diseases, Rheumatoid Arthritis, SLE.
Primary outcome: Frequency and grade of each solicited local and systemic adverse events (AEs); Frequency and grade of any unsolicited AEs (including 'significant disease flares'*).
Enrollment: 220 participants.
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 220 participants or records.
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