The role of non-coding RNAs derived from macrophage exosomes in cardiovascular diseases
Abstract
Cardiovascular disease is the predominant cause of mortality globally, with both morbidity and mortality rates escalating annually. Non-coding RNAs are essential in the regulation of cardiovascular disease. Exosomes are lipid bilayer vesicles that are released by many types of cells. They carry biomolecules such as proteins and nucleic acids (e.g. microRNAs, circular RNAs and long non-coding RNAs). The physiological condition of the mother cell significantly affects their composition and biological activity. In cardiovascular disorders, macrophages generate exosomes that facilitate intercellular communication, potentially resulting in new therapeutic strategies for these conditions. In this article, we examine the impact of exosomal non-coding RNAs derived from macrophages on the functionality and condition of immune cells, vascular smooth muscle cells, endothelial cells, cardiomyocytes and cardiac fibroblasts. They facilitate intercellular communication via several mechanisms. Non-coding RNAs generated from macrophage exosomes significantly influence cellular functional states and might offer new approaches for preventing and treating cardiovascular disorders. Owing to insufficient clinical evidence, additional extensive investigations are required to assess the therapeutic potential of these non-coding RNAs in cardiovascular disorders.
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