Real-World, Multicenter Evaluation of the Incidence and Risk Factors for Non-susceptible Stenotrophomonas maltophilia Isolates
Abstract
BACKGROUND
Stenotrophomonas maltophilia is a cause of infection most commonly in the opportunistic host. Trimethoprim-sulfamethoxazole and levofloxacin are considered first line treatment agents. With reports of increasing resistance to these first line agents it is important to determine risk factors associated with a non-susceptible isolate.
METHODS
This was a real-world, multicenter, retrospective case-control study from five centers in the southeast United States evaluating S. maltophilia. The primary outcome was risk factors associated with non-susceptibility of S. maltophilia isolates to ≥1 antimicrobial agent. Secondary outcomes include incidence of S. maltophilia non-susceptibility, all-cause mortality, and 30-day readmission rates.
RESULTS
There were 325 patients included in the study. For the primary outcome, the only factor associated with non-susceptibility per univariate analysis was isolation from urine culture (13.3% vs. 5.4%; p=0.014); while presence of mechanical ventilation (37.7% vs. 21.5%) and ICU admission (35.3% vs. 18.4%) were associated with susceptibility (p<0.001). For the secondary outcomes, non-susceptibility was present in 49% of isolates with 43/325 (13.2%), 53/324 (16.4%), and 105/172 (61%) to TMP-SMX, levofloxacin, and ceftazidime, respectively. Resistance to chloramphenicol and tigecycline was observed among 5/26 and 11/16 of tested isolates, respectively. Sixty-six patients (20%) experienced all-cause, inpatient mortality (18% susceptible…
How strong is the evidence?
Evidence Hub reads this as a case-control. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 325 participants or records.
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