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hnRNP F: An emerging orchestrator of RNA processing and gene expression

Wang Z, Huang H, Li H

iScience, 2026

Abstract

Heterogeneous nuclear ribonucleoprotein F (hnRNP F), a member of the hnRNP family, is an essential regulator of RNA metabolism, influencing splicing, translation, stability, and telomere maintenance. This review provides a comprehensive overview of the regulation of expression and multifunctional roles of hnRNP F. Owing to the high degree of sequence homology and functional similarity between hnRNP F and hnRNP H/H', this review also integrates discussions on hnRNP H/H' to facilitate a comparative and holistic understanding of their biological significance.

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