Therapeutic Targeting of Long Non-Coding RNAs in Cancer
Abstract
Long non-coding RNAs (lncRNAs) represent a significant population of the human transcriptome. Many lncRNAs exhibit cell and/or tissue/tumor specific expression making them excellent candidates for therapeutic applications. In this review we discuss examples of lncRNAs that demonstrate the diversity of their function in various cancer types. We also discuss recent advances in nucleic acid drug development with a focus on oligonucleotide-based therapies as a novel approach to inhibit tumor progression. The increased success rates of nucleic acid therapeutics provides an outstanding opportunity to explore lncRNAs as viable therapeutic targets to impact various aspects of cancer progression.
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