Site-specific bacteriology of tropic ulcers and their antibiotic sensitivity: A cross-sectional study
Abstract
Introduction: The trophic ulcers are usually presented in the form of diabetic ulcer, leprotic ulcer, and pressure ulcer. The usual site for ulceration in trophic ulcer is the bony prominence on body part devoid of sensation. The chronic wounds management in health-care setting have significant impact on the patient's physical, mental, and financial health. In trophic ulcer management factors such as cause of ulcer, its location, size, and duration should be considered. Infection in such trophic ulcer leads to increase disease activity results delayed wound healing. Thus, a study was designed with aim to find relation between location of trophic ulcer and its infection status. Materials and Methods: This retrospective cross-sectional study includes 95 patients with infected trophic ulcers admitted between January 2015 and March 2020 from our tertiary care rehabilitation center. Cultured bacterial species were tested against following 23 drugs Amikacin, Gentamycin, Levofloxacin Ciprofloxacine, Piperacillin + Tazobactum, Ceftriaxone, Cefepime, Meropenem, Imipenem, Ampicillin, Ceftazidime, Amoxiclav, Cotrimoxazole, Cefotaxime, Erythromycin, Clindamycin, Tetracycline, Cefoxitin, Chloramphenicol, Colistin, Tobramycin, Vancomycin, and Aztreonam. Results: The common sites of trophic ulcer involvement were sacrum (32%), heel (29%), forefoot (17%), ischium (12%), knee (6%), and greater trochanter (4%). Eight different bacterial species were isolated, which were Staphylococcus aureus…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 95 participants or records.
Read the paper
Related studies
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Photochemical behavior of levofloxacin
- Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio
- Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides
- Synthesis of [11C]levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.