Evaluation of Antimicrobial Susceptibility Patterns to Oral Fluoroquinolones among Uropathogens Isolated from the Paediatric Population in Eastern India: A Cross-Sectional Analysis
Abstract
Background: Urinary tract infections (UTIs) are among the most frequent bacterial infections affecting children and constitute a major cause of emergency department visits, outpatient management, and hospitalization. Antimicrobial resistance among commonly isolated uropathogens has become a significant public health challenge, limiting therapeutic options and complicating empirical management. Fluoroquinolones, including ciprofloxacin and levofloxacin, are widely used oral antibiotics due to their broad antimicrobial coverage, excellent urinary penetration, and favourable pharmacokinetic properties. However, regional variability in antimicrobial resistance significantly influences treatment outcomes. Objective: To determine the magnitude of culture-positive paediatric urinary tract infections in a tertiary care hospital in Eastern India and to evaluate and compare antimicrobial susceptibility to ciprofloxacin and levofloxacin among isolated uropathogens. Materials and Methods: A descriptive cross-sectional study was conducted over nine months from October 2023 to June 2024, involving 268 culture-confirmed paediatric UTI cases. Urine samples were collected using sterile midstream clean-catch technique and processed using standard microbiological procedures. Identification and antimicrobial susceptibility testing were performed according to Clinical and Laboratory Standards Institute (CLSI 2023) guidelines using the Kirby–Bauer disk diffusion technique. Statistical evaluation…
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Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
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