Long non-coding RNA CRNDE in cancer prognosis: Review and meta-analysis
Abstract
BACKGROUND
Colorectal neoplasia differentially expressed (CRNDE), a 1910-nt lncRNA encoded on human chromosome 16, has been found to be involved in various cancers. Nevertheless, the clinical and diagnostic values of CRNDE in tumors still need to be explored. In this review, we aimed to elucidate the clinical role of CRNDE in cancer by searching all correlative literature, and we sequentially explored the association between CRNDE levels and overall survival (OS) or clinicopathological characteristics of cancer.
METHODS
We conducted a database search of PubMed, Wanfang Data, Ovid, SinoMed, China National Knowledge Infrastructure, Cochrane Library, and Web of Science (up to January 1, 2018). The pooled odds ratio (OR) and hazard ratio (HR) were used to assess extents of correlation between CRNDE and cancer prognosis. After identification of the inclusion and exclusion criteria, 12 articles including 1361 patients were selected for this review.
RESULTS
The results suggested that high levels of CRNDE were highly related to poor OS in tumor patients, with pooled HRs of 2.314 (1.894-2.826, P < .001, fixed-effects model). Likewise, we also found that high CRNDE expression was correlated with high tumor stage [OR: 3.340, 95% confidence interval (CI): 2.417-4.616, P < .001, random-effects model] and lymph node metastasis (OR: 3.027, 95% CI: 2.071-4.425, P = .004, random-effects model).
CONCLUSIONS
Our findings demonstrated that CRNDE may modify susceptibility for various cancers and…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 1,361 participants or records.
Read the paper
Related studies
- Regulation of nucleolus assembly by non-coding RNA polymerase II transcripts
- For a Healthy Histone Code, a Little SUMO in the Tail Keeps the Acetyl Away
- Discovering a binary CTCF code with a little help from BORIS
- Article Commentary: Stabilizing the Code–-Methods to Preserve RNA Prove Their Worth
- Foreword to the Special Issue for the RINTC (The Implicit Seismic Risk of Code-Conforming Structures) Project
- Commentary: Promoting Health and Well-being in Pediatric Primary Care Settings: Using Health and Behavior Codes at Routine Well-child Visits
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.