Bibliometric and visual analysis of omega-3 polyunsaturated fatty acids in cancer research (2000-2025)
Abstract
Objective: Omega-3 polyunsaturated fatty acids (PUFAs) have received considerable attention as potential adjunctive agents in antitumor therapy. However, systematic bibliometric analyses of this research area remain limited. This study aims to systematically examine research trends, knowledge hotspots, and emerging themes related to omega-3 PUFAs in oncology from 2000 to 2025, with the goal of providing valuable insights for future investigations.
Methods: Records related to omega-3 PUFAs and oncology published between 2000 and 2025 were retrieved from the Web of Science Core Collection and Scopus. Bibliometric mapping was performed using R/bibliometrix, VOSviewer, and CiteSpace. In addition, clinical trial records from PubMed were screened to summarize clinical progress in this field.
Results: A total of 2,917 publications from the Web of Science and 7,380 publications from Scopus were analyzed. From 2000 to 2025, the annual number of publications in this field increased gradually, then reached a plateau, followed by a slight decline. The United States was the leading contributor in terms of publication output (n = 819), followed by China (n = 391) and Italy (n = 171). The United States also demonstrated a broader international collaboration network. Nutrients published the largest number of articles (n = 98, IF = 5.0), whereas the American Journal of Clinical Nutrition received the highest number of citations (n = 5,299, IF = 6.9). Major research themes included…
How strong is the evidence?
Evidence Hub reads this as a systematic review, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 5,299 participants or records.
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