Neural representations of visual memory in inferotemporal cortex reveal a generalizable framework for translating between spikes and field potentials
Abstract
Translating neurophysiological findings requires understanding the relationship between common measures of brain activity in animals (spiking activity) and humans (local field potentials, LFP). Prior work suggests alignment between population spiking and high-gamma activity (HGA, 50-150 Hz) of the LFP; however, this is not always observed and is consequently debated. Here, we show that this alignment and prior failures depend on the underlying coding scheme. First, we examined neural representations of variables related to visual memory in macaque inferotemporal cortex. We found that spikes and HGA were strikingly aligned for variables encoded as population response magnitude (novelty, recency, and memorability). However, a variable encoded as a distributed pattern of activity (category) was misaligned. Next, we showed that these insights generalize across many published studies, accounting for prior alignment successes and failures. These results provide a framework for translating between spikes and LFPs, highlighting the scenarios likely to be fruitful for translation.
Read the paper
Related studies
- Regulation of nucleolus assembly by non-coding RNA polymerase II transcripts
- For a Healthy Histone Code, a Little SUMO in the Tail Keeps the Acetyl Away
- Discovering a binary CTCF code with a little help from BORIS
- Article Commentary: Stabilizing the Code–-Methods to Preserve RNA Prove Their Worth
- Foreword to the Special Issue for the RINTC (The Implicit Seismic Risk of Code-Conforming Structures) Project
- Commentary: Promoting Health and Well-being in Pediatric Primary Care Settings: Using Health and Behavior Codes at Routine Well-child Visits
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.