2002-2022 Quinolone Resistance in Escherichia coli of Swine in Mainland China: A Meta-Analysis
Abstract
Simple Summary In this study, we assessed the evolution of resistance to quinolone antibiotics in swine-derived Escherichia coli in mainland China from 2002 to 2022 by meta-analysis. Fifty-three studies were included after systematic searches of PubMed, Web of Science, and CNKI databases, and the resistance rates were calculated using random-effects models and Freeman–Tukey double-orthogonal string transformation. The results showed that the overall resistance rates of the four quinolone antibiotics were, in order, enrofloxacin (54%), ciprofloxacin (50%), ofloxacin (43%) and levofloxacin (37%). Subgroup analyses showed that the resistance rate was significantly higher in the eastern region than in the western region, but there was no significant change in the resistance rate before and after 2018, and the testing method did not significantly affect the results. Although China has restricted the use of some quinolone veterinary drugs since 2016, the resistance rate did not decrease significantly, which may be related to the continued use of alternative drugs and the diverse spread of resistance genes. This study reveals the critical situation of quinolone resistance in swine-derived E. coli, highlights the public health risk of the cross-species transmission of resistance genes, and provides an important basis for optimizing veterinary antibiotic management.
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in animal, not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Photochemical behavior of levofloxacin
- Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio
- Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides
- Synthesis of [11C]levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.