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The Genetic Code--Yesterday, Today, and Tomorrow

Francis Harry Compton Crick

Cold Spring Harbor Symposia on Quantitative Biology, 1966

161 citations

Abstract

This is an historic occasion. There have been many meetings about the genetic code during the past ten or twelve years but this is the first impor-tant one to be held since the code became known. When I came to the States early in 1965 I brought w&h me tentative allocations for many of the 64 triplets. based mainly on the early work of Leder and Nirenberg, the results from the random poly-mers and the mutagenesis data. I telephoned Marshall Nirenberg, who told me of his latest allocations. A little later I saw Gobind Khorana and heard the first results he was getting using polymers with repeating sequences. I also visited George Streisinger and was told about the pre-liminary amino acid sequences due to a phase shift

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