Long non-coding RNA profiling of hypertrophic cardiomyopathy in mice
Abstract
Long non-coding RNAs (lncRNAs) are transcripts that do not typically code for protein but have essential roles in the regulation of transcription and translation in health and disease. Hypertrophic cardiomyopathy (HCM) is a commonly inherited cardiovascular disease. While a number of studies have described transcriptional regulation in human heart tissue and animal models of HCM, whether lncRNA plays a role in the pathophysiology of HCM remains unknown. We present an RNA-Seq dataset on left ventricle samples from transgenic HCM TNNT2 ∆160 mice (n = 31) and non-transgenic (n = 33) mice (n = 64 total) in which differentially expressed lncRNAs are delineated. We determined the mouse lncRNA genes that have a human ortholog, which may be useful for future investigators aiming to study the role of particular lncRNAs in human HCM.
How strong is the evidence?
Evidence Hub reads this as a dataset, done in animal, not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health. Reported size: 64 participants or records.
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