Effect of topical povidone-iodine 10% plus levofloxacin 0.5% one hour before cataract surgery in eliminating perioperative conjunctival flora: randomized clinical trial
Abstract
PURPOSE
To evaluate the effect of a single administration of topical povidone-iodine (PVI) 10% plus levofloxacin 0.5%, at 1 hour before cataract surgery, on perioperative elimination rate of conjunctival flora.
SETTING
Poostchi Ophthalmology Research Center, Shiraz, Iran.
DESIGN
Randomized controlled trial.
METHOD
Patients who required cataract surgery were randomly assigned to one of two groups: intervention (administration of PVI 10% plus levofloxacin at 1 hour before surgery) or control. The patients in both groups received PVI just before the operation. Conjunctival cultures were obtained using thioglycollate broth at 4 timepoints including T1: before intervention; T2: before the second application of PVI; T3: 3 minutes after the second administration of PVI; and T4: just after the surgery.
RESULTS
The study comprised 142 patients.The comparative rates of positive cultures in the intervention vs control groups were as follows: T1 (70.4% vs 73.2%; P=0.709); T2 (15.5% % vs 71.8%; P<0.001,); T3 (7.0% vs 19.7%; P=0.027); and T4 (5.6% vs 4.2%; P=0.698). Coagulase negative Staphylococci was the most common isolated microorganism.
CONCLUSIONS
Results showed that a single adjuvant application of PVI 10% plus levofloxacin 0.5% eyedrops at 1 hour before operation leads to a further increase in the rate of sterile conjunctiva just before the surgery.
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 142 participants or records.
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