Fertilisation Promoting Peptide: a key player in male fertility/subfertility?
Abstract
'Male factor' problems contribute to subfertility in a significant proportion of couples. In some instances, defective sperm production has qualitative and/or quantitative effects on the semen profile; in others, no obvious defects can be detected, yet spermatozoa are non-fertilising. Recent studies have revealed that fertilisation promoting peptide (FPP), which is structurally related to thyrotrophin releasing hormone (TRH) and found in the prostate gland and seminal plasma of many mammals, has important biologically relevant effects on both mouse and human spermatozoa. In the presence of physiological concentrations of FPP, spermatozoa become fertile more quickly and are then inhibited from undergoing spontaneous acrosome loss, a step that would render them non-fertilising. In vivo, these responses could be extremely important in maximising fertilising potential of the few spermatozoa that reach the site of fertilisation. Prostatic dysfunction results in decreased production of FPP and increased production of less bioactive FPP-related peptides. A putative receptor (TCP-11) for FPP has been identified in the mouse; the gene (with a human homologue) which codes for TCP-11 resides within a complex known to contain genes affecting male fertility. These results strongly suggest that FPP plays an important role in normal fertility and that it might therefore provide both new therapeutic approaches for some cases of unexplained infertility and new approaches for male…
How strong is the evidence?
Evidence Hub reads this as a editorial / letter, done in animal, not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Regulation of nucleolus assembly by non-coding RNA polymerase II transcripts
- For a Healthy Histone Code, a Little SUMO in the Tail Keeps the Acetyl Away
- Discovering a binary CTCF code with a little help from BORIS
- Article Commentary: Stabilizing the Code–-Methods to Preserve RNA Prove Their Worth
- Foreword to the Special Issue for the RINTC (The Implicit Seismic Risk of Code-Conforming Structures) Project
- Commentary: Promoting Health and Well-being in Pediatric Primary Care Settings: Using Health and Behavior Codes at Routine Well-child Visits
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.