Spectroscopic Characterization and Biological Activity of Mixed Ligand Complexes of Transition Metals with Levofloxacin and Phenyl Azo compounds
Abstract
Mixed ligand complexes of the type [Levo.- M-(L 1 - L 4 )], where M = Co (II), Ni(II), Cu(II) and Zr (IV), Levo. is levofloxacin drug as a primary ligand and L 1 -L 4 are four azo compounds as secondary ligands, were prepared and characterized by elemental analysis, molar conductivity, FT-IR, UV-Vis spectroscopy, magnetic moments, and thermogravimetric (TG&DTA) analysis. Spectral and elemental analysis data showed that both levofloxacin drug and the secondary ligands azo compounds act as monovalent monodentate coordinating to the metal ion via OO fashion in levofloxacin and through ON fashion in the secondary ligands with octahedral geometry in all cases. The crystal field splitting energy ( ∆ o ), Racah parameter (B'), nephelauxetic ratio (β) , Sinha parameter (δ %) (metal – ligand covalency percent) and the covalency angular overlap parameter (η) h ave been calculated using the Tanabe Sugano diagram. The antimicrobial activity of the mixed ligand complexes has been studied by screening against some gram positive and gram negative bacteria, where it was found that they have enhanced activity. The antitumor activities of some selected complexes were tested against HEPG2 cell line and compared to that of Vinblastine as a standard drug.
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