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Intra- and inter-multi-omics interaction analysis using deep learning

Kang M, Jang E, Mersha TB

Bioinformatics advances, 2026

Abstract

Multi-omics interactions, including intra- and inter-omics interactions as well as socio-environmental influences, are key to uncovering molecular mechanisms that may be missed by individual omics analysis or conventional integration approaches. Deep learning offers a promising solution to overcome current limitations, including the complexity of modeling high-dimensional, nonlinear interactions, limited sample size and multiple testing burden.

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