Non-coding RNA: It’s Not Junk
Abstract
Since the three-dimensional structure of DNA was discovered by Watson and Crick in 1953, progress in the understanding of the arrangement of the human genome occurred slowly at first. After the initial breakthrough in deducing the double helical structure of DNA, it took 11 years to recognize and decipher the triplet code for amino acids, and another 15 years to recognize that eukaryotic genes are interrupted by non-coding introns separating the exons. Although it gradually became apparent that protein coding genes are like occasional charms on a very long bracelet, the reason why such long stretches of non-coding existed was unknown.
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