Non-coding RNAs in cardiovascular health and disease
Abstract
Cardiovascular disease is a worldwide epidemic. Even though new therapies are emerging, cardiac remodeling and subsequent heart failure remain critical issues after myocardial infarction with high rates of mortality. Because of the high death rate and the economic burden for society, researchers are exploring uncharted territory aiming to improve our understanding of the underlying processes of heart disease, with the ultimate goal to devise new strategies for therapeutic intervention. A previously unrecognized class of molecules, so called noncoding RNAs (ncRNA), is moving into the focus as valid therapeutic targets to tackle heart disease in (pre-)clinical settings [1]. With the advent of modern molecular biology techniques like next generation sequencing, it has become clear that the majority of the genome is transcribed into RNA, while only 2% of the transcribed genome encodes proteins. The transcribed portion of the genome that does not code for proteins is known as non-coding RNA. These noncoding RNAs include ribosomal RNAs, transfer RNAs, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). MiRNAs and lncRNAs are relatively recently discovered and play important roles in posttranscriptional and epigenetic gene expression regulation and are often expressed in a cell-type-specific manner [1]. In this special issue, several review papers cover recent advances in non-coding RNA research in the field of cardiovascular disease. Two publications provide an overview of…
Read the paper
Related studies
- Regulation of nucleolus assembly by non-coding RNA polymerase II transcripts
- For a Healthy Histone Code, a Little SUMO in the Tail Keeps the Acetyl Away
- Discovering a binary CTCF code with a little help from BORIS
- Article Commentary: Stabilizing the Code–-Methods to Preserve RNA Prove Their Worth
- Foreword to the Special Issue for the RINTC (The Implicit Seismic Risk of Code-Conforming Structures) Project
- Commentary: Promoting Health and Well-being in Pediatric Primary Care Settings: Using Health and Behavior Codes at Routine Well-child Visits
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.