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Effectiveness of physiotherapy in male premature ejaculation. A systematic review and metaanalysis

Medrano-Sánchez EM, López-Del-Castillo A, Boisseau M, Fernández-Domínguez JC, Díaz-Mohedo E

The journal of sexual medicine, 2026

416 participants

Abstract

INTRODUCTION

Premature ejaculation (PE) is clinically defined as an intravaginal ejaculatory latency time (IELT) of 1 min or less. While pharmacological treatments have demonstrated rapid and effective results, they are frequently associated with adverse side effects. In contrast, physiotherapeutic approaches offer a safer alternative, with a lower risk of undesirable reactions.

OBJECTIVES

To assess the efficacy of physiotherapeutic interventions in increasing IELT, compared to pharmacological treatment, in men diagnosed with PE.

METHODS

A systematic search was conducted across multiple databases (PubMed, PEDro, Scopus, and Researchgate) to identify clinical trials published within the past 10 years. Eligible studies included those that compared physiotherapy with pharmacological interventions, using IELT as the primary outcome variable in male patients with PE. A quality assessment was performed using the PEDro scale. The data were pooled and a meta-analysis was completed. This systematic review was conducted in accordance with the (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) PRISMA guideline statement. It was registered in the PROSPERO database with registration number CRD42024613802 (blinded for reviewers).

RESULTS

Six studies, encompassing a total of 416 participants, met the inclusion criteria and were analyzed. The pooled effect is statistically significant (P = .03), showing a mean difference in IELT of -0.80 s (95% confidence interval, -1.53…

How strong is the evidence?

Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 416 participants or records.

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