Improving Solubility and Dissolution Characteristics of Dapoxetine Hydrochloride through the Liquisolid Compact Method
Abstract
This study aimed to enhance the solubility and dissolution properties of Dapoxetine hydrochloride (DXH) tablets by using
of novel method i.e., liquisolid compact technology (LCT). A total of 9 formulations of DXH tablets were prepared by
using carrier materials like microcrystalline cellulose and coating materials like lactose, silica, and starch. In out of nine
formulations Super disintegrants like cross povidone (CP) in F1–F4 and Cross Carmellose Sodium in F5–F9 added. All
formulations were evaluated for both pre compressional and post compressional evaluation parameters. Based on the
evaluation parameters, the F6 formulation exhibited superior dissolution characteristics compared to others, indicating
enhanced solubility rates. In vitro dissolution studies showed significantly improved release rates for DXH tablets.X-ray
diffraction (XRD) analysis revealed a reduction in crystallinity, further supporting enhanced dissolution. Scanning electron
microscopy (SEM) confirmed uniform dispersion of drug particles in the optimized formulation, leading to improved drug
release. The absence of notable interactions between the drug and excipients was confirmed via FTIR analysis, ensuring
formulation stability. In conclusion, LCT effectively enhanced the dissolution rate of DXH, demonstrating its potential as
a promising approach for improving poorly water-soluble drugs.
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