Efficacy of Adding Sildenafil to Dapoxetine in the Treatment of Dapoxetine Nonresponding Mono-symptomatic Premature Ejaculation
Abstract
Background: Primary premature ejaculation (PE) has been treated with selective serotonin reuptake inhibitors; however these medications have a low success rate. Aim: The aim is to evaluate the efficacy and safety of adding sildenafil to dapoxetine for patients with premature, symptomatic ejaculation who did not respond to dapoxetine alone. Patients and methods: This randomized controlled trial was conducted at the urology outpatient centers of Al-Azhar University, Al-Hussein Hospital, and Sayed Galal Hospital. This research included 200 male PE patients placed into two groups. For 8 weeks, 110 patients in group A got sildenafil 50 mg as an additional treatment to dapoxetine 30 mg. Group B consisted of 90 participants who received dapoxetine 30 mg with a placebo for the same duration as group A. Results: The study included 200 PE cases with no erectile dysfunction. Group A showed an increased International Index of Erectile Function (IIEF) score and improved PE diagnostic tool results. Posttreatment intravaginal ejaculatory latency time (IVLT) was significantly changed among groups, with 48 patients in group A having a posttreatment IVLT of more than or equal to 4 min compared to 19 in group B. There were also significant differences in the sex satisfaction scale after treatment, with 27.3% of patients in group A being extremely satisfied compared to 15.6% in group B. Conclusion: Dapoxetine and sildenafil combination treatment for patients with PE without erectile dysfunction…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 200 participants or records.
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