(221) on-demand paroxetine for premature ejaculation - systematic review and meta-analysis
Abstract
This review aims to compare the efficacy of On-demand Paroxetine to on-demand Dapoxetine and Placebo for the treatment of Premature Ejaculation.
In patients with premature ejaculation, does on-demand Paroxetine increase the Intravaginal ejaculatory latency time compared to on-demand Dapoxetine therapy?
Electronic databases were systematically searched to identify the eligible Randomized Controlled Trials, comparing on-demand Paroxetine to Dapoxetine or placebo, following the Cochrane Collaboration methodology. Non-randomized trials were excluded.
The Protocol for this systematic review was prospectively registered on PROSPERO - International Prospective Register of Systematic Reviews with the reference number CRD42022316352.
Highly sensitive search strategies were designed following the PRISMA-S guidelines to search the MEDLINE, Cochrane CENTRAL, EMBASE, PsycINFO, and other bibliographic databases. Subject terms (MeSH) "Premature Ejaculation", "Paroxetine", "Dapoxetine", and "on-demand" were adapted to each database for a comprehensive literature search. Results are reported in line with PRISMA guidelines. 1171 abstracts were identified for screening by two independent reviewers using the Covidence software. Full-text screening of the 30 records was performed. The meta-analysis included nine eligible randomized controlled trials, recruiting a total of 721 participants. Meta-analysis was performed using the Cochrane Collaboration's Review manager software.
Meta-analysis of…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 721 participants or records.
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