Interventions for premature ejaculation: Rapid systematic review and meta-analysis
Abstract
Background: Premature ejaculation (PE) is commonly defined as ejaculation with minimal sexual \nstimulation before, on or shortly after penetration and before the person wishes it. PE can be either \nlifelong and present since first sexual experiences (primary), or acquired (secondary), beginning \nlater (Godpodinoff ML. Premature ejaculation: clinical subgroups and etiology. J Sex Marital Ther \n1989;15:130–4). Treatments include behavioural and pharmacological interventions. \nObjective: To systematically review evidence for clinical effectiveness of behavioural, topical and systemic \ntreatments for PE. \nData sources: The following databases were searched from inception to 6 August 2013 for published \nand unpublished research evidence: MEDLINE; EMBASE; Cumulative Index to Nursing and Allied Health \nLiterature; The Cochrane Library including the Cochrane Systematic Reviews Database, Cochrane \nControlled Trials Register, Database of Abstracts of Reviews of Effects and the Health Technology \nAssessment database; ISI Web of Science, including Science Citation Index, and the Conference \nProceedings Citation Index-Science. The US Food and Drug Administration website and the European \nMedicines Agency (EMA) website were also searched. \nMethods: Randomised controlled trials (RCTs) in adult men with PE were eligible (or non-RCTs in the \nabsence of RCTs). RCT data were extrapolated from review articles when available. The primary outcome \nwas intravaginal ejaculatory…
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