037 Efficacy and Tolerability of Dapoxetine and Sertraline for the Treatment of Chinese Patients With Premature Ejaculation
Abstract
Premature ejaculation (PE) is one of the most prevalent male sexual dysfunction, and can have a detrimental effect on self-confidence and on interpersonal relationships. Pharmacotherapy with selective serotonin reuptake inhibitor (SSRI) represents the most efficacious treatment option for PE. To compare the efficacy and tolerability of dapoxetine and sertraline pharmacotherapy for the treatment of PE. From January 2015 to June 2015, a total of 117 patients with PE seeking treatment in our hospital were randomly assigned (2:1) to receive either dapoxetine 30 mg 1-3 h before planned sexual intercourse (n=78) or sertraline 50 mg once daily for 1 month (n=39). Intravaginal ejaculatory latency time (IELT), clinical global impression of change (CGIC) score, Premature Ejaculation Profile (PEP) and treatment-emergent adverse events (TEAEs) were recorded as outcomes. Both groups experienced significantly increased IELT after pharmacotherapy (dapoxetine-treated group: from 0.87 min to 2.84 min; sertraline-treated group: from 0.84 min to 2.71 min). The CGIC rating regarding PE was reported to be much better or better in 36.5% and 37.5% of dapoxetine and sertraline-treated patients, respectively. At least a slightly better CGIC rating was reported by 63.6% and 71.9%, respectively, of dapoxetine-treated and sertraline-treated groups. The incidence of adverse events that include dizziness (12.5% vs. 9.5%), nausea (9.4% vs. 6.3%), headache (6.3% vs. 3.2%), and diarrhea (6.3% vs. 3.2%)…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 117 participants or records.
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