PS-01-011 Efficacy and tolerability of dapoxetine and sertraline for the treatment of Chinese patients with premature ejaculation
Abstract
To compare the efficacy and tolerability of dapoxetine and sertraline pharmacotherapy for the treatment of PE. From January 2015 to June 2015, a total of 117 patients with PE seeking treatment in our hospital were randomly assigned (2:1) to receive either dapoxetine 30 mg 1-3 h before planned sexual intercourse (n = 78) or sertraline 50 mg once daily for 1 month (n = 39). Intravaginal ejaculatory latency time (IELT), clinical global impression of change (CGIC) score, Premature Ejaculation Pro_le (PEP) and treatment-emergent adverse events (TEAEs) were recorded as outcomes. Both groups experienced significantly increased IELT after pharmacotherapy (dapoxetine-treated group: from 0.87 min to 2.84 min; sertraline-treated group: from 0.84 min to 2.71 min). The CGIC rating regarding PE was reported to be much better or better in 36.5% and 37.5% of dapoxetine and sertraline-treated patients, respectively. A slightly better CGIC rating was reported by 63.6% and 71.9%, respectively, of dapoxetine-treated and sertraline-treated groups. The incidence of adverse events that include dizziness (12.5% vs 9.5%), nausea (9.4% vs 6.3%), headache (6.3% vs 3.2%), and diarrhea (6.3% vs 3.2%) after sertraline therapy showed a slightly higher trend than that after dapoxetine therapy (P>0.05); while the incidence of fatigue (3.2% vs 18.8%), somnolence (1.6% vs 15.6%) and dry mouth (0% vs 12.5%) was significantly lower after dapoxetine therapy compared with sertraline treatment (P<0.05). Although…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 117 participants or records.
Read the paper
Related studies
- Improving the translation of search strategies using the Polyglot Search Translator: a randomized controlled trial
- Nutritional, Physical, Cognitive, and Combination Interventions and Frailty Reversal Among Older Adults: A Randomized Controlled Trial
- Clinical characteristics and risk factors associated with COVID-19 severity in patients with haematological malignancies in Italy: a retrospective, multicentre, cohort study
- A randomized, controlled trial of oral propranolol in infantile hemangioma
- Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study
- Increased physical activity improves sleep and mood outcomes in inactive people with insomnia: a randomized controlled trial
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.