HP-08-003 Acceptance and discontinuation rates of dapoxetine treatment in Chinese patients with premature ejaculation
Abstract
Dapoxetine hydrochloride is a selective serotonin reuptake inhibitor (SSRI) and it is the first drug approved for on-demand treatment of premature ejaculation (PE) in China. The efficacy and safety profiles of dapoxetine have been established by worldwide clinical trials. These studies report that approximately 30% of patients receiving dapoxetine therapy will discontinue treatment. To date, the rate of dapoxetine treatment discontinuation has not been reported.This study aims to investigate the rates of acceptance and discontinuation from dapoxetine treatment in Chinese patients with PE. The rates of dapoxetine therapy acceptance and discontinuation of 181 consecutive patients seeking treatment for PE from January 2014 to December 2014 were analyzed. Patients completed a range of assessments including: a detailed medical and sexual history; premature ejaculation diagnostic tool (PEDT); self-reported intravaginal ejaculatory latency time (IELT); and self-administered international index of erectile function-5 (IIEF-5). All patients received dapoxetine (30 mg on-demand) for 4 weeks, and then followed up by visits in the outpatient clinic or via telephone. The rates of acceptance and discontinuation from dapoxetine therapy were recorded. Reasons for treatment discontinuation were investigated.
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