Association between 5-HTTLPR and STin2 VNTR polymorphisms in the serotonin transporter gene and clinical response of a selective serotonin reuptake inhibitor (dapoxetine) in lifelong premature ejaculation
Abstract
To the Editor: Premature ejaculation (PE) is one of the commonplace male sexual dysfunctions affecting about 30% of men worldwide. PE can either be lifelong or acquired. Genetic polymorphisms situated on the SLC6A4 of humans encoding the 5 -hydroxytryptamine transporter (serotonin transporter) ( 5 -HTT) also called the serotonin transporter (SERT), a signi fi cant controller of serotonergic neurotransmission, were related to the pathogenesis of PE. [1,2] Polymorphisms in SLC6A4 are associated with the incidence of lifelong premature ejaculation (LPR). The effects of 5-hydroxytryptamine (serotonin) transporter gene-linked polymorphic region (5-HTTLPR) and serotonin transporter gene intron 2 (STin2) polymorphism on lifelong PE (LPE) are controversial. We aimed to determine possible relationships between 5-HTTLPR and STin2 polymorphisms in the SERT gene and clinical response of a selective serotonin reuptake inhibitor (dapoxetine) in LPE. We the The patients and have
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