Formulation and Evaluation of Dapoxetine HCL Nanoparticle Capsules
Abstract
The goal of any drug delivery system is to provide a therapeutic amount of drug to the proper site in the body and also to achieve and maintain the desired drug concentration.
The λ max of Dapoxetine Hcl as found to be 292 nm in 0.01N Hydrochloric acid and 292nm in Phosphate buffer pH6.8 in 10μg/ml solution.
Dapoxetine Hcl is a highly potent SSRI was used as a model drug to develop a controlled release formulation. Dapoxetine Hcl designed to prolong the release increase the drug bioavailability, diminish the side effects of irritating drugs and also reducing the frequency of administration, thereby improving the patient compliance and therapeutic efficacy.
The Dapoxetine Hcl obeys the Beers law within the concentration of 5 to 50 μg/ml.
Dapoxetine Hcl is having low solubility and short duration elimination half life (1-1.6 hour), the drug displays extensive first pass metabolism.
The purpose of this study was to prepare Dapoxetine Hcl nanoparticles for control release of Dapoxetine Hcl to improve the oral bioavailability, enhance the solubility and dissolution rate by decreasing particle size of drug.
Infrared spectroscopic studies confirmed that there was no interaction between drug and polymers.
The controlled release Dapoxetine Hcl nanoparticles were prepared by Solvent evaporation by using Ethyl cellulose, Chitosan & HPMC K100 M and hyper-cross linked method using Betacyclodextrin and Diphenyl carbonate polymers of 1:1, 1:2, 1:3, 1:4 ratios.
The production yield of the…
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