AB151. Clinical study on the treatment of lifelong premature ejaculation with paroxetine hydrochloride and tamsulosin
Abstract
BACKGROUND AND OBJECTIVE: There are some methods for the treatment of primary premature ejaculation (PE) at present, but its efficacy and safety is not very good and the effectiveness of some treatment method remains to be further confirmed. Psychotherapy and behavior training therapy has a poor adherence for patients. The surgical treatment to PE has not been widely recognized by experts because its effect of uncertainty and may cause irreversible damage. So, pharmaceutical drug therapy is usually recommended as the first priority selection for the treatment of PE. At present, only the dapoxetine was specifically developed for the treatment of PE worldwide. Other off-label selective serum reuptake inhibitor substance (SSRIs) such as paroxetine, fluoxetine; local anesthetics such as lidocaine, prilocaine cream; PDE5 inhibitor such as tadalafil, sildenafil and vardenafil; selective alpha-adrenergic receptor blockers such as tamsulosin, silodosin was also used for the treatment of PE. Owing to the individual differences and the different causes of PE, the efficacies of one medicine in different patients are different. So, individual-based treatment could be the trend for the treatment of PE according to the specific causes and its classification. There is quite a few researches focus on the combination treatment of SSRIs and α-receptor blockers to PE. In this study, the efficacy and safety using paroxetine and hydrochloric tamsulosin for the treatment of PE were evaluated, the…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 225 participants or records.
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