(222) possible pathophysiological roles of neurotransmitter systems in MEN with lifelong premature ejaculation: a scoping review
Abstract
Abstract Introduction Lifelong premature ejaculation (LPE) is a subtype of premature ejaculation. Genetic research on LPE has primarily focused on neurotransmitters like serotonin, dopamine, and norepinephrine. LPE treatment studies have focused on drugs like serotonin reuptake inhibitors (SSRIs). However, findings from both genetic association and pharmacotherapeutic studies have been inconsistent, likely due to the lack of standardized definitions and measurement methods for LPE, such as the stopwatch method for clocking intravaginal ejaculation latency times (IELTs). In addition, some genetic studies in LPE have shown to be prone to genotyping errors which has led to inconclusive results. Objective To provide a quality assured overview of neurobiological targets that are potentially associated with LPE by investigating genetic and pharmacotherapeutic studies. Methods This scoping review was conducted using the preferred reporting items for systematic reviews and meta-analyses extension for scoping reviews (PRISMA-ScR tool). Five databases were searched in March 2023 without timeline- or language-related restrictions. We included pharmacological studies with multiple study designs: randomized clinical trials, cross-over studies, single arm trials or case reports. Studies were only eligible if pre- and posttreatment stopwatch measured IELTs were reported in order to measure a factor increase in IELTs. Studies that did not use the ISSM 2008 or 2014- or the DSM-5 definition…
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