Combination or alone ? Which one is best in premature ejaculation treatment?
Abstract
Şentürk et al., Combination or Alone ? Which one is Best in Premature Ejaculation Treatment? / doi: 10.14744/hnhj.2018.87699 ter or based on an estimation.While measurement with chronometer has the advantage of measuring more objectively, IELT measured by self-estimation and chronometer can accurately determine the duration of premature ejaculation with 80% sensitivity and 80% specificity [2]. The 5-hydroxy tryptamine (5-HT) neurotransmitter has been shown to play an important role in the ejaculation control process. In at least three subgroups, studies have shown that the 5-HT receptor is widely distributed in the seminal vesicle, vas deferens, lumbosacral, and thoracic spinal cord [3, 4]. When all this pathophysiology is evaluated, several proposed pharmacotherapies for the treatment of premature ejaculation include topical agents, creams, sprays, and systemic therapies. The use of serotonin in the treatment of premature ejaculation has been widespread nowadays since it has been determined serotonin is inhibiting the ejaculation in different ways and accomplishing this procedure via SSRIs [5]. Six different agents, i.e.,citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, and a new drug dapoxetine, are used in the systematic treatment [6]. Recently, selective serotonin reuptake inhibitors such as dapoxetine and paroxetine have been used as first-line treatment in the treatment of premature ejaculation, and dapoxetine has been used specifically in the treatment of…
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