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Editorial Comment to Impact of low‐dose tadalafil on adverse events after low‐dose‐rate brachytherapy for prostate cancer: A bi‐center randomized open‐label trial

N. Haga, T. Miyazaki, Kazuna Tsubouchi, Y. Okabe

International journal of urology, 2021

Abstract

ized prostate cancer: Seattle experience. Int. J. Radiat. Oncol. Biol. Phys. 2011; 81: 376–81. 2 Caffo O, Fellin G, Bolner A et al. Prospective evaluation of quality of life after interstitial brachytherapy for localized prostate cancer. Int. J. Radiat. Oncol. Biol. Phys. 2006; 66: 31–7. 3 Chen AB, D’Amico AV, Neville BA, Earle CC. Patient and treatment factors associated with complications after prostate brachytherapy. J. Clin. Oncol. 2006; 24: 5298–304. 4 Stone NN, Stock RG. Complications following permanent prostate brachytherapy. Eur Urol. 2002; 41: 427–33. 5 Merrick GS, Butler WM, Wallner KE, Lief JH, Galbreath RW. Prophylactic versus therapeutic alpha-blockers after permanent prostate brachytherapy. Urology 2002; 60: 650–5. 6 Tsumura H, Satoh T, Ishiyama H et al. Comparison of prophylactic naftopidil, tamsulosin, and silodosin for 125I brachytherapy-induced lower urinary tract symptoms in patients with prostate cancer: randomized controlled trial. Int. J. Radiat. Oncol. Biol. Phys. 2011; 81: e385–e392. 7 McVary KT, Roehrborn CG, Kaminetsky JC et al. Tadalafil relieves lower urinary tract symptoms secondary to benign prostatic hyperplasia. J. Urol. 2007; 177: 1401–7. 8 Curran M, Keating G. Tadalafil. Drugs 2003; 63: 2203–12. 9 Brock GB, McMahon CG, Chen KK et al. Efficacy and safety of tadalafil for the treatment of erectile dysfunction: results of integrated analyses. J. Urol. 2002; 168: 1332–6. 10 Wang Y, Bao Y, Liu J, Duan L, Cui Y. Tadalafil 5 mg Once Daily Improves…

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Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.

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