1019 From Hormones to the Bed: Does Thyroid Function Modulate Sexual and Sleep Health in Men from the Cross-Sectional EPISONO Cohort?
Abstract
Erectile dysfunction (ED) and sleep disturbances are highly prevalent conditions that share neuroendocrine, metabolic, and autonomic pathways. Evidence suggests bidirectional interactions between thyroid function, sleep physiology, and sexual health. This study investigated whether thyroid hormones interact with ED status to influence objective sleep parameters in adult men.
This cross-sectional study used data from the 4th edition of the São Paulo Epidemiological Sleep Study (EPISONO), conducted in 2018, which included 769 adults (317 men). After excluding individuals who reported the use of sleep-related medications (benzodiazepines, Z-drugs, melatonin), thyroid medications, or tadalafil, as well as those without essential hormonal or sleep data, the final sample comprised 286 men (230 without ED; 56 with ED). ED status was defined by self-report. All participants underwent full-night polysomnography and morning fasting blood collection for hormonal assessment of thyroid-stimulating hormone (TSH), free thyroxine (FT4), total thyroxine (T4), and total triiodothyronine (T3). Generalized Linear Models adjusted for age and body mass index (BMI) compared hormonal and sleep outcomes between ED groups. Interaction effects between ED and thyroid hormones (TSH, FT4) on sleep outcomes were evaluated using moderation models.
No significant differences were observed between groups for TSH, T4, FT4, or T3. Men with ED showed a markedly altered sleep architecture, with a lower…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 769 participants or records.
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