Choroidal Thickness Values Following the Consumption of Sildenafil and Tadalafil: Comparison of the OCT Records
Abstract
Objective: The aim of this study is to demonstrate the anatomic and physiologic changes in the choroid following systemic sildenafil and tadalafil.
Methods: This cross-sectional randomized study enlisted 20 young and healthy men, who were randomly and equally classified in two groups; group a received 50 mg of Sildenafil, whereas group B received 10 mg of Tadalafil. All participants underwent a measurement of choroidal thickness, based on enhanced depth imaging optical coherence tomography (EDI-OCT). The measurement was repeated two hours after the consumption of each PDE-5 inhibitor.
Results: The mean age of participants was 34.2 ± 3.0 and 34.6 ± 3.2 years in group A and B, respectively. The mean values of choroidal thickness (CT) in Group A at baseline were 306.6 ± 11.1 μm, 229.9 ± 12.7 μm and 311.3 ± 21.8 μm in temporal, nasal and inferior quadrants, respectively. The mean increase in choroidal thickness in Group A two hours after receiving sildenafil was 29.9 μm, 23.8 μm and 34.2 μm in temporal (CI [-35.18,-24.62], p<0.001), nasal (CI [-27.20,-20.40], p<0.001) and inferior (p=0.005) quadrants, respectively. On the other hand, the mean values of choroidal thickness in Group B at baseline were 307.2 ± 10.6 μm, 227.4 ± 8.9 μm and 315.8 ± 9.1 μm in temporal, nasal and inferior quadrants, respectively. Significant raise was also noted in Group B two hours after tadalafil intake in temporal (13.2 μm, CI [-17.77,-8.63], p<0.001), nasal (12.7 μm, CI [-14.75,-10.65], p<0.001) and…
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Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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