Is the concentration of potassium in ejaculate capable to be the predictor of clinical efficacy of tadalafil in men with chronic prostatitis 3 B?
Abstract
Introduction. For objective assessment of the functional status of prostatic tissue, the «KAlium Parameter of Laboratory analysis, Evaluating in Ejaculate (KAPLEE)» was offered. KAPLEE is the concentration of K ions, measuring with the help of potentiometry in 42 ml of water solution, which contains 1 ml of ejaculate, 39 ml of distilled water and 2 ml of special buffer solution. The aim – to check the hypothesis that the deviation of KAPLEE from the normal range towards reduction or towards increase is the predictor of less efficacy of tadalafil in patients with CP3B. Materials and methods: In trial 36 patients with the diagnosis of CP3B, who received tadalafil 5 mg once a day for 30 days as monotherapy, took part. During first stage each patient evaluated the efficacy of this pharmacotherapy in his case; it varied from 1 point (absolute non-efficacy) to 5 points (absolute efficacy). Then each patient ejaculated into container, and the concentration of KAPLEE was measured. Thus, the data of each patient were placed in two-axial system of coordinates: axis of abscisses was the concentration of KAPLEE, axis of ordinates was the mark of efficacy. Then the cluster analysis of these data was made. Results and conclusion. The concentration of kalium in ejaculate is the predictor of tadalafil efficacy in men with CP3B. Normal values of KAPLEE are associated with high efficacy of tadalafil, its deviations are predictors of low efficacy.
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health. Reported size: 36 participants or records.
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