Syphilis and the risk of stroke: a nationwide, population-based matched cohort study
Abstract
OBJECTIVES
Syphilis has re-emerged globally recently. However, valid data on stroke risk after syphilis infection are limited. We aimed to assess the risk of stroke among patients with syphilis and to account for family-related factors as well as confounding by test indication.
METHODS
We conducted a nationwide, population-based matched cohort study in Denmark using linked registry and laboratory data from 2000 to 2022. Individuals aged 16-80 years with a positive syphilis serology test were matched 1:9 on sex and date of birth to individuals from the general population. To address confounding by test indication, a syphilis test-negative cohort was matched 1:1 to the syphilis-positive cohort. To assess familial and shared environmental factors, sibling cohorts corresponding to each primary cohort were included. Stroke incidence was ascertained through hospital registries. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated using Cox regression, and cumulative incidence functions were used to estimate absolute risk.
RESULTS
The study included 3593 syphilis test-positive individuals, 3590 syphilis test-negative individuals, and 32 629 individuals from the general population contributing over 300 000 person-years of follow-up. The median age was 36 years, and 81% were male. The 10-year cumulative risk of stroke among syphilis-positive individuals was 1.8% (95% CI: 1.3-2.4). Stroke risk was markedly higher among syphilis-positive individuals compared with the…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 32 participants or records.
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