Peyronie’s disease in Spain: a prospective study
Abstract
Abstract Background Peyronie’s disease (PD) research has limitations due to heterogeneity in time of presentation, severity, deformity characteristics, and associated conditions. Aim To provide further insight into clinical characteristics of patients, PD treatments and patient perceptions of outcomes in clinical practice in Spain. Methods A total of 601 men from 15 Spanish andrology centers were included in this observational, prospective multicenter cohort study. Enrolled patients (aged ≥18 years with confirmed PD diagnosis, naïve to specific therapy and without congenital penile curvature) were evaluated by detailed medical history and physical examination including plaque characteristics and curvature. Sexual function was assessed by the International Index of Erectile Function-5 and the Peyronie’s Disease Questionnaire. The characteristics of treatment used for PD as well as patient subjective outcomes were analyzed in cases involving curvature assessments. Outcomes The primary outcome was demographic and clinical characterization of PD patients; secondary outcomes included PD treatment used in clinical practice and patient satisfaction. Results The median age (interquartile range, IQR) was 57 (49.0-63.0) years with a median duration of PD of 12 (6.0-18.0) months. There were 246 (41.6%) patients in the acute phase of the disease. The most common nonsurgical treatments were traction therapy (36.0%), collagenase injections (29.3%), and daily tadalafil (22.7%). The most…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 601 participants or records.
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