Serum CRP and Fibrinogen Levels as Inflammatory Biomarkers Before and After Oral Daily Tadalafil 5 mg Treatment in Patients with Erectile Dysfunction: Case-Control Study
Abstract
Background: Erectile dysfunction [ED] is the inability to obtain and maintain an erection appropriate for sexual activity. estimated one in ten adult males experience ED on a long-term basis.Aim of the work: We aimed to assess endothelial biomarkers [C-reactive protein and fibrinogen] before and after Platelet-Rich Plasma versus daily Tadalafil 5 mg and evaluate the role of Platelet-Rich Plasma in vasculogenic erectile dysfunction.Patients and Methods: This research had been conducted on 40 cases with vasculogenic ED and 10 normal healthy individuals as a control. Patients were divided into two groups; group 1 which included 20 ED patients who received daily Tadalafil 5 mg, and group 2 which included 20 ED patients who were injected with Platelet-Rich Plasma. CRP and Fibrinogen were collected from all patients before and after treatment.Results: The findings in this study supported that Tadalafil has a higher value in treatment in male patients with ED. As regards the Peak systolic velocity [PSV], it significantly increased from 17±1.07 cm/s before tadalafil treatment to 27.37±1.24cm/s after it [P value = 0.04]. Also, it was significantly increased in the PRP group from 13±1.02 cm/s at the baseline to 25.37±1.33 cm/s after it [P value = 0.013]. The difference between the two groups at the baseline was significant statistically [P value = 0.03] [Table 2], however after treatment we found no statistically significant difference between the 2 groups [P value = 0.1].Conclusion:…
How strong is the evidence?
Evidence Hub reads this as a case-control, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 20 participants or records.
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